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After improving on a brutal 0-for-3 performance in Week 8 with a slightly better 1-for-3 showing in Week 9, let’s see if we can start the month of November off right as we tackle Week 10 today.
Unfortunately, this week’s presumed headliner between Ohio State and Penn State is not the top-10 matchup we thought it would be, to put it lightly.
Vanderbilt vs. Texas, however, is a can’t miss top-20 matchup that keeps the noon slate intriguing, and there are several other big games on tap later today.
Now, without further ado, your Week 10 CFB picks against the spread …
West Virginia at No. 22 Houston (-12.5)
Kickoff: 12 p.m. ET (FS1)
The Cougars (7-1, 4-1 Big 12) are having an impressive season, including a 24-16 win on the road over Sam Leavitt and Arizona State last Saturday.
Former Texas A&M QB Conner Weigman has been sharp all year for the Cougars, with his only blemish coming in an ugly loss to Texas Tech back in early October.
Since then, Weigman has thrown seven touchdowns and zero interceptions, carving up Oklahoma State, Arizona and Arizona State to put the Cougars in the thick of the Big 12 title race.
This conference has been unpredictable, to say the least, for years, but betting against West Virginia has been a winning formula in 2025.
The Mountaineers (2-6, 0-5 Big 12) kept last week’s loss to TCU close, but they’ve lost three conference games this year by at least 30 points. They also lost to Ohio in nonconference play.
Another one-sided loss by West Virginia today wouldn’t surprise me at all. This could, however, be a tricky game for Houston if WVU true freshman Scotty Fox Jr. can build on a promising performance a week ago (28-for-41 passing, for 301 yards and two TDs) in his second career start.
Pick: Houston -12.5 (best odds: -115 at DraftKings)
No. 18 Oklahoma at No. 14 Tennessee (-2.5)
Kickoff: 7:30 p.m. ET (ABC)
As we spelled out earlier this week, it’s hard not to like Tennessee at home in primetime.
John Mateer and the OU offense have just not played well enough since his early-season thumb injury for me to recommend backing the Sooners (6-2, 2-2 SEC) on the road against one of the top offenses in the country.
The Vols (6-2, 3-2 SEC) have struggled to get stops in SEC play, but their offense has been outstanding just about every week. The OU D is formidable, but we saw last week in a loss to Ole Miss that a great offense with a veteran QB can move the ball on the Sooners. Vols QB Joey Aguilar and Co. certainly fit that bill.
Winning in Knoxville at night is almost impossible, even for top offensive teams, and OU has hardly been one since a hot start by Mateer that made him an early-season Heisman candidate.
I’m not convinced Tennessee will necessarily light up the scoreboard, but I expect it to score enough to pull out a close one and cover this tight spread.
Pick: Tennessee -2.5 (best odds: -118 at DraftKings)
Hawaii at San Jose State (-1.5)
Kickoff: 10:30 p.m. ET (CBSSN)
Is it just me, or is the wrong team favored here?
He’s flown under the radar the last three weeks, but QB Micah Alejado and Hawaii (6-2, 3-1 Mountain West) are on a three-game winning streak, with each of those wins coming as the betting underdog.
The 5-foot-10 redshirt freshman has been outstanding after missing time early this year with an injury. He has three straight games with at least 300 yards passing, including 400-yard nights in wins over Air Force and Utah State.
Following a bye week, against a San Jose State team that is just 2-6 (1-2 Mountain West) on the year, I’m not sure why Hawaii is catching points.
The Spartans have allowed at least 28 points in six straight games. That makes it hard to see them getting enough stops to take down a Hawaii team averaging almost 30 points per game despite missing its starting QB for multiple games.
Over 55.5 (-115 at FanDuel) is also tempting here.
Pick: Hawaii moneyline (best odds: +106 at FanDuel)
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